Despite the significant clinical advances with the use of immune checkpoint inhibitors (ICIs) in a wide range of cancer patients, response rates to the therapy are variable and do not always result in long-term tumor regression.The development of ICI-resistant disease is one of the pressing issue in clinical oncology, and the identification of new
Abstract The determination of protein in urine is important in clinical examination along with other parameters in urine.The presence of protein in urine can be interpreted that there is a disorder in kidney.Acid and heat coagulations method is still widely used in many areas to determine protein in urine.In this method, the characteristic of prote
Abstract Purpose Pectus excavatum (PE) is the most common congenital chest wall deformity.It can have a negative effect in exercise tolerance.However, cosmetic features are the most frequent concerns in these patients.The PE evaluation questionnaire (PEEQ) is a patient reported outcome (PRO) tool to measure the physical and psychosocial quality-of-
Optical vortices (OVs), as eigenmodes of optical orbital angular momentum, have been widely used in particle micro-manipulation.Recently, perfect optical vortices (POVs), a subclass of OVs, are gaining increasing interest and becoming an indispensable tool in optical trapping due to their unique property of topological charge-independent vortex rad
Interactions between macromolecules orchestrate many mechanobiology processes.However, progress in the field has often been hindered by the monetary and time costs of obtaining reliable experimental structures.In recent years, deep-learning methods, such as AlphaFold, have democratized access to high-quality predictions of the structural properties